Negative regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR18, NPM3, and SGTA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus WDR18 in PANCREAS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	WDR18 →	+0.896	+1.761	<.001	<.001	3	8
LUNG_NSCLC_LUAD	NPM3 →	+0.603	+0.877	.002	.003	3	7
LUNG_SCLC	SGTA →	+0.811	+0.387	<.001	<.001	3	7
STOMACH	MYG1 →	+1.001	+0.769	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	HMCES →	+0.719	+1.428	.003	<.001	3	7
URINARY_TRACT	ZC3H12A →	-1.624	-1.462	.007	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs WDR18 — PANCREAS

Explore this scatter interactively →