Negative regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STIP1, CLNS1A, and EIF3I, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus STIP1 in URINARY_TRACT (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	STIP1 →	+1.808	+1.375	<.001	.001	3	19
PANCREAS	CLNS1A →	+2.299	+2.231	<.001	<.001	3	19
OVARY	EIF3I →	+1.736	+1.302	<.001	<.001	3	19
LUNG_NSCLC_LUSC	SGTA →	+2.990	+1.544	.002	.005	3	19
URINARY_TRACT	UBXN1 →	+2.832	+1.620	<.001	.005	3	19
URINARY_TRACT	CCT2 →	+1.612	+1.254	<.001	.005	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs STIP1 — URINARY_TRACT

Explore this scatter interactively →