Regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Regulation of ERAD pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBQLN2, BIRC2, and HCN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBQLN2 grouped by Regulation of ERAD pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UBQLN2 →	-0.461	-1.523	.003	<.001	3	6
BREAST	BIRC2 →	-0.187	-0.883	.006	.001	3	5
UPPER_AERODIGESTIVE_TRACT	HCN4 →	-0.171	-0.326	.001	.003	2	5
OVARY	RNF185 →	-0.304	-1.344	<.001	<.001	3	4
LIVER	USP25 →	-0.277	-1.115	.005	.008	2	5
OVARY	NPTX1 →	-0.271	-1.024	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBQLN2 by Regulation of ERAD pathway activity — SOFT_TISSUE

Explore this box plot interactively →