Regulation of ERAD pathway

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of ERAD pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Regulation of ERAD pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

UCS, HNSC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.523	0.153	.002	24	view →
HNSC	DFS	Median	IV	0.610	0.485	.013	21	view →
KIRP	DFS	Quartile	All	0.547	0.617	.018	21	view →
GBM	OS	Quartile	All	0.277	0.436	.004	19	view →
OV	DFS	Tertile	IV	0.343	0.604	.008	18	view →
ESCA	DFS	Tertile	III,IV	0.508	0.238	.033	15	view →
COAD	OS	Median	IV	0.699	0.398	.005	13	view →
UVM	DFS	Quartile	III,IV	0.295	0.620	.024	12	view →
KICH	OS	Median	III,IV	0.907	0.508	.031	11	view →
SCLC	OS	Median	IV	0.201	0.772	.024	9	view →
BRCA	OS	Median	IV	0.957	0.501	.010	8	view →
BLCA	DFS	Median	IV	0.140	0.267	.030	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:1904292–UCS (DFS)

Open the UCS breakdown →