Negative regulation of membrane depolarization

Across TCGA patient cohorts, RNA activity of the Negative regulation of membrane depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, UBR5, and PES1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane depolarization activity versus SMC4 in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	-0.587	-0.109	<.001	<.001	3	7
LSCC	UBR5 →	-0.238	-0.114	<.001	<.001	3	7
LSCC	PES1 →	-0.393	-0.108	<.001	<.001	3	7
LSCC	KDM3A →	-0.578	-0.127	<.001	<.001	3	7
LSCC	MCM7 →	-0.633	-0.111	<.001	<.001	3	7
HNSC	DDX58 →	+0.749	+0.134	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904180 vs SMC4 — BRCA

Explore this scatter interactively →