Positive regulation of adipose tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCBTB1, TGFB1, and EXOSC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adipose tissue development activity versus RCBTB1 in KIDNEY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RCBTB1 →	-1.210	-0.206	.008	.001	3	4
SKIN	TGFB1 →	-2.152	-1.007	.001	.003	3	4
LARGE_INTESTINE	EXOSC9 →	-0.829	-0.623	<.001	.008	3	4
LARGE_INTESTINE	RABEP1 →	-0.897	-0.567	<.001	.009	3	4
OVARY	STX19 →	+1.070	+0.666	.003	.008	3	4
LUNG_NSCLC_LUAD	KIRREL1 →	-2.054	-0.603	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904179 vs RCBTB1 — KIDNEY

Explore this scatter interactively →