Regulation of monoatomic anion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of monoatomic anion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, NEK2, and TK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monoatomic anion transmembrane transport activity versus HROB in UCEC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HROB →	-0.755	-0.710	<.001	.001	3	4
UCEC	NEK2 →	-1.045	-0.644	<.001	.004	3	4
HNSC	TK1 →	-0.887	-0.128	.003	.005	2	5
GBM	PPFIBP1 →	-0.309	-0.535	.004	<.001	3	3
HNSC	SMPD4 →	-0.424	-0.127	<.001	.001	3	3
GBM	HMGA1 →	-0.650	-0.572	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903959 vs HROB — UCEC

Explore this scatter interactively →