Regulation of establishment of T cell polarity

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of T cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFD1, BRCA2, and ZFPM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTHFD1 grouped by Regulation of establishment of T cell polarity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTHFD1 →	+0.658	+1.019	.002	<.001	3	6
LUNG_NSCLC_LUAD	BRCA2 →	+0.685	+0.721	.002	.009	2	6
BLOOD_Lymphoma	ZFPM1 →	+1.437	+1.547	.004	<.001	3	5
SKIN	D2HGDH →	+0.893	+1.031	<.001	.006	3	4
KIDNEY	EMC8 →	+0.702	+1.432	.004	<.001	2	5
LIVER	CLBA1 →	-1.220	-1.060	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTHFD1 by Regulation of establishment of T cell polarity activity — CNS

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