Negative regulation of IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Negative regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNMA8A, KTN1, and SERPINE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of IRE1-mediated unfolded protein response activity versus PNMA8A in LUAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PNMA8A →	-0.938	-0.448	.004	.004	3	4
GBM	KTN1 →	+0.271	+0.087	.004	.004	3	3
GBM	SERPINE2 →	-0.642	-0.124	.004	<.001	3	3
GBM	PLEKHF1 →	-0.509	-0.113	.005	.004	3	3
UCEC	CIP2A →	-0.775	-0.131	.003	.005	3	3
PDAC	ELK3 →	-0.501	-0.918	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903895 vs PNMA8A — LUAD

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