Negative regulation of IRE1-mediated unfolded protein response

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of IRE1-mediated unfolded protein response pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of IRE1-mediated unfolded protein response pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.583	0.857	<.001	43	view →
BRCA	DFS	Tertile	III,IV	0.938	0.830	.008	37	view →
CESC	DFS	Median	All	0.388	0.702	<.001	30	view →
SKCM	DFS	Tertile	All	0.648	0.537	.007	28	view →
LUAD	DFS	Tertile	III,IV	0.785	0.375	.010	20	view →
STAD	DFS	Median	All	0.467	0.624	<.001	19	view →
ESCA	OS	Tertile	III,IV	0.717	0.362	.010	16	view →
SCLC	OS	Median	II,III,IV	0.501	1.000	.012	13	view →
DLBC	DFS	Median	All	0.579	0.929	.001	12	view →
UVM	OS	Median	III,IV	0.406	1.000	.030	9	view →
CHOL	DFS	Tertile	All	0.735	0.138	.022	9	view →
PRAD	DFS	Median	All	0.963	0.913	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:1903895–KIRP (DFS)

Open the KIRP breakdown →