Extraembryonic membrane development

Across TCGA patient cohorts, RNA activity of the Extraembryonic membrane development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, TOP2A_S1247, and TPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extraembryonic membrane development activity versus SMC4 in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.691	+0.054	<.001	<.001	3	8
UCEC	TOP2A_S1247 →	+1.057	+0.076	<.001	<.001	3	8
UCEC	TPX2 →	+0.818	+0.085	<.001	<.001	3	8
GBM	CHAF1B →	+0.690	+0.056	<.001	<.001	3	8
GBM	MCM3 →	+0.710	+0.052	<.001	<.001	3	8
UCEC	SLBP_S23 →	+0.473	+0.061	.004	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903867 vs SMC4 — GBM

Explore this scatter interactively →