Regulation of cellular response to transforming growth factor beta stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A13, SIN3A, and MYO3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC39A13 grouped by Regulation of cellular response to transforming growth factor beta stimulus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC39A13 →	-0.385	-0.227	<.001	.004	3	4
LUNG_NSCLC_LUSC	SIN3A →	-0.315	-0.204	.002	.002	2	5
URINARY_TRACT	MYO3A →	+0.181	+0.211	.001	<.001	3	4
PANCREAS	USP14 →	-0.223	-0.254	.002	<.001	3	4
STOMACH	PTPN5 →	+0.164	+0.166	.006	<.001	3	3
OESOPHAGUS	PRDM13 →	-0.185	-0.189	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC39A13 by Regulation of cellular response to transforming growth factor beta stimulus activity — OVARY

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