Negative regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP7B, SRGAP1, and PRODH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP7B grouped by Negative regulation of miRNA processing-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP7B →	-0.984	-1.062	.006	<.001	3	4
OVARY	SRGAP1 →	-1.387	-1.182	.009	.001	3	4
BREAST	PRODH →	-2.269	-0.880	.001	<.001	3	3
BREAST	TMEM254 →	-0.790	-0.870	.005	.003	3	3
BREAST	PSTPIP2 →	-1.408	-1.158	<.001	<.001	3	3
BREAST	POLL →	-0.629	-1.304	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP7B by Negative regulation of miRNA processing activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →