Regulation of establishment of protein localization to mitochondrion

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COG5, COG7, and EFL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of protein localization to mitochondrion activity versus COG5 in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COG5 →	-0.224	-0.049	<.001	<.001	3	6
GBM	COG7 →	-0.231	-0.042	.001	<.001	3	5
GBM	EFL1 →	-0.181	-0.031	<.001	.001	2	6
LSCC	CD163 →	+0.416	+0.040	<.001	<.001	3	5
UCEC	GBP5 →	+0.838	+0.040	<.001	.007	3	5
LSCC	HLA-E →	+0.399	+0.040	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903747 vs COG5 — GBM

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