Regulation of establishment of protein localization to mitochondrion

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of establishment of protein localization to mitochondrion pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Regulation of establishment of protein localization to mitochondrion pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and BLCA, show the opposite pattern, with higher activity associated with better survival.

BRCA, BLCA, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.922	0.741	<.001	48	view →
BLCA	OS	Median	III,IV	0.780	0.606	<.001	47	view →
HNSC	DFS	Tertile	All	0.454	0.269	.006	47	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	32	view →
LIHC	OS	Tertile	All	0.710	0.845	.002	22	view →
UCS	DFS	Median	II,III,IV	0.476	0.182	.023	18	view →
PAAD	OS	Tertile	All	0.477	0.709	.009	17	view →
SCLC	DFS	Quartile	All	0.810	0.483	.009	16	view →
LUAD	DFS	Median	II,III,IV	0.556	0.363	.020	16	view →
ACC	DFS	Quartile	All	0.395	0.713	.012	12	view →
KIRP	DFS	Quartile	All	0.446	0.697	.005	10	view →
LUSC	OS	Quartile	III,IV	0.171	0.864	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1903747–BRCA (OS)

Open the BRCA breakdown →