Positive regulation of phospholipid metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of phospholipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX21, KANK2, and RAI14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid metabolic process activity versus SNX21 in LUAD (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNX21 →	+0.549	+0.119	<.001	<.001	3	7
BRCA	KANK2 →	+0.419	+0.060	.002	<.001	3	7
BRCA	RAI14 →	+0.338	+0.045	<.001	<.001	3	7
BRCA	FILIP1L →	+0.404	+0.045	<.001	<.001	3	7
LSCC	PRKG1 →	+0.475	+0.079	<.001	<.001	3	7
GBM	DAB2 →	+0.581	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903727 vs SNX21 — LUAD

Explore this scatter interactively →