Positive regulation of phospholipid metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of phospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF286B, PRC1-AS1, and KCNK6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid metabolic process activity versus ZNF286B in HNSC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF286B →	-0.420	-0.120	.007	.004	3	6
LSCC	PRC1-AS1 →	-0.523	-0.199	<.001	<.001	3	5
GBM	KCNK6 →	+0.488	+0.256	<.001	<.001	3	5
UCEC	PRKCD →	+0.721	+0.189	<.001	<.001	3	5
LSCC	PSMC3IP →	-0.534	-0.186	<.001	<.001	3	5
BRCA	SEPTIN3 →	-1.131	-0.187	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903727 vs ZNF286B — HNSC

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