Regulation of phospholipid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMB1, EIF3E, and RPL30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid metabolic process activity versus LAMB1 in LUNG_SCLC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LAMB1 →	+2.253	+0.303	.005	.001	2	7
OESOPHAGUS	EIF3E →	-0.991	-0.209	<.001	<.001	3	5
OESOPHAGUS	RPL30 →	-0.955	-0.223	<.001	<.001	3	5
OESOPHAGUS	RPL12 →	-1.026	-0.245	.001	.002	3	5
BONE	LAMC1 →	+2.702	+0.480	.001	<.001	3	5
BONE	THBS1 →	+6.452	+0.527	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903725 vs LAMB1 — LUNG_SCLC

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