"Positive regulation of wound healing, spreading of epidermal cells"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHLDB1_S678, PPFIBP1_S794, and UBE2O, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of wound healing, spreading of epidermal cells" activity versus PHLDB1_S678 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHLDB1_S678 →	+0.598	+0.085	.007	<.001	3	5
LSCC	PPFIBP1_S794 →	+0.476	+0.075	<.001	<.001	3	5
LSCC	UBE2O →	-0.211	-0.069	<.001	<.001	3	4
PDAC	CCN1 →	+0.582	+0.060	<.001	.005	3	4
HNSC	TPD52 →	-0.477	-0.074	.003	.002	2	5
HNSC	EIF3J →	-0.175	-0.051	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903691 vs PHLDB1_S678 — LSCC

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