"Regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRINA, NTAQ1, and MBNL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRINA grouped by "Regulation of wound healing, spreading of epidermal cells"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GRINA →	+0.135	+0.090	.004	.004	3	4
SKIN	NTAQ1 →	-0.229	-0.075	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MBNL2 →	+0.271	+0.085	.008	.002	3	4
BLOOD_Lymphoma	PLA2G15 →	+0.255	+0.277	.002	.008	3	4
SKIN	DACH1 →	+0.143	+0.088	.001	.001	3	4
SKIN	ACOT13 →	+0.259	+0.123	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRINA by "Regulation of wound healing, spreading of epidermal cells" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →