"Regulation of wound healing, spreading of epidermal cells"

Across TCGA pan-cancer cohorts, RNA activity of the "Regulation of wound healing, spreading of epidermal cells" pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher "Regulation of wound healing, spreading of epidermal cells" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and LAML, show the opposite pattern, with higher activity associated with better survival.

MESO, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	All	0.232	0.502	<.001	68	view →
UVM	OS	Quartile	III,IV	0.353	1.000	.002	62	view →
LGG	DFS	Median	All	0.475	0.329	<.001	47	view →
LAML	DFS	Median	All	0.683	0.453	.002	30	view →
LUSC	OS	Quartile	III,IV	0.269	0.691	<.001	25	view →
KIRC	OS	Tertile	All	0.748	0.613	.008	18	view →
PRAD	DFS	Quartile	All	0.917	0.717	.014	16	view →
THCA	DFS	Tertile	II,III,IV	0.769	0.935	.006	15	view →
BLCA	DFS	Quartile	All	0.544	0.675	.025	13	view →
STAD	DFS	Quartile	All	0.475	0.635	.007	12	view →
UCEC	DFS	Quartile	IV	0.658	0.290	.009	12	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:1903689–MESO (DFS)

Open the MESO breakdown →