"Regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI35, SLC12A9, and TMEM217, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of wound healing, spreading of epidermal cells" activity versus IFI35 in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IFI35 →	-1.699	-0.875	.001	.002	3	4
OVARY	SLC12A9 →	-1.187	-0.544	<.001	.008	3	4
OVARY	TMEM217 →	-0.723	-0.457	<.001	.007	3	4
OVARY	GAS1 →	-1.857	-0.526	<.001	.001	3	4
OVARY	TMEM102 →	-0.868	-0.391	.002	.006	2	5
OVARY	HBP1 →	-0.901	-0.685	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903689 vs IFI35 — BREAST

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