Positive regulation of sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, AMOTL1, and IRAG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sprouting angiogenesis activity versus RPS5 in UCEC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS5 →	-0.145	-0.042	<.001	<.001	3	6
BRCA	AMOTL1 →	+0.429	+0.042	<.001	<.001	3	6
UCEC	IRAG1 →	+0.486	+0.036	<.001	<.001	3	6
UCEC	JCAD_S1044 →	+0.932	+0.049	<.001	.001	3	6
UCEC	PPFIBP1_S540 →	+0.540	+0.052	<.001	<.001	3	6
BRCA	COL5A2 →	+0.614	+0.029	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903672 vs RPS5 — UCEC

Explore this scatter interactively →