Regulation of sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, PALM2AKAP2, and CYGB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sprouting angiogenesis activity versus TNS2 in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2 →	+0.595	+0.036	<.001	<.001	3	9
BRCA	PALM2AKAP2 →	+0.613	+0.040	<.001	<.001	3	9
OV	CYGB →	+0.617	+0.040	<.001	<.001	3	9
LSCC	SHROOM4_S299 →	+0.549	+0.050	.001	<.001	2	9
UCEC	SYNPO2 →	+0.846	+0.051	<.001	<.001	3	8
UCEC	TNS1 →	+0.716	+0.049	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903670 vs TNS2 — BRCA

Explore this scatter interactively →