Regulation of complement-dependent cytotoxicity

Across TCGA patient cohorts, RNA activity of the Regulation of complement-dependent cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL10A1, LINC00702, and ZNF365, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of complement-dependent cytotoxicity activity versus COL10A1 in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL10A1 →	+1.127	+0.107	<.001	<.001	3	6
BRCA	LINC00702 →	+0.381	+0.119	<.001	<.001	3	6
BRCA	ZNF365 →	+0.725	+0.160	<.001	<.001	3	5
BRCA	LOXL1 →	+1.378	+0.197	<.001	<.001	3	5
BRCA	LMOD1 →	+0.644	+0.133	.001	<.001	3	5
BRCA	ARHGAP20 →	+0.391	+0.156	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903659 vs COL10A1 — BRCA

Explore this scatter interactively →