Protein localization to photoreceptor outer segment

Across TCGA patient cohorts, RNA activity of the Protein localization to photoreceptor outer segment pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, RPS5, and TMOD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to photoreceptor outer segment activity versus TLN2 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TLN2 →	+0.392	+0.066	.003	<.001	3	8
GBM	RPS5 →	-0.236	-0.062	<.001	.001	3	8
GBM	TMOD2 →	+0.288	+0.042	.004	.002	3	8
UCEC	SARM1 →	+0.484	+0.091	.001	.005	3	7
UCEC	STXBP1 →	+0.362	+0.062	.005	.003	2	8
LUAD	DDX21_S89 →	-1.011	-0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903546 vs TLN2 — CCRCC

Explore this scatter interactively →