Protein localization to photoreceptor outer segment

Across TCGA cell cohorts, RNA activity of the Protein localization to photoreceptor outer segment pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKMY2, TNFRSF1B, and PPP1R9B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKMY2 grouped by Protein localization to photoreceptor outer segment-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ANKMY2 →	+1.611	+1.505	<.001	<.001	3	5
BLOOD_Lymphoma	TNFRSF1B →	+4.995	+2.099	.008	.002	2	5
LUNG_SCLC	PPP1R9B →	+0.655	+1.181	.007	.009	2	5
LUNG_NSCLC_LUSC	CD70 →	+3.862	+1.871	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	IDH1 →	+1.998	+2.040	<.001	<.001	3	4
OESOPHAGUS	TP53I13 →	+1.045	+0.580	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKMY2 by Protein localization to photoreceptor outer segment activity — UPPER_AERODIGESTIVE_TRACT

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