Positive regulation of mitotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, TOM1L2, and UNG_T60, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cytokinesis activity versus TOP2A_S1247 in LUAD (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+1.631	+0.224	<.001	<.001	3	10
BRCA	TOM1L2 →	-0.375	-0.080	<.001	<.001	3	9
PDAC	UNG_T60 →	+0.872	+0.162	<.001	<.001	3	9
HNSC	XPO5 →	+0.508	+0.121	<.001	<.001	3	9
LSCC	HEATR1 →	+0.370	+0.121	<.001	<.001	3	9
GBM	MRTO4 →	+0.363	+0.096	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903490 vs TOP2A_S1247 — LUAD

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