Protein localization to ciliary membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to ciliary membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP250, TNFRSF10B, and SMARCA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP250 grouped by Protein localization to ciliary membrane-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CEP250 →	-1.136	-0.848	.001	.007	3	5
STOMACH	TNFRSF10B →	+1.711	+1.407	<.001	.007	2	6
LUNG_NSCLC_LUAD	SMARCA2 →	+1.047	+0.972	.006	<.001	3	5
BLOOD_Leukemia	DOCK5 →	+1.895	+1.006	.006	.002	3	4
BLOOD_Myeloma	HSPBAP1 →	+0.896	+1.344	.001	<.001	3	4
BLOOD_Myeloma	YTHDC2 →	+1.030	+1.405	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP250 by Protein localization to ciliary membrane activity — LUNG_SCLC

Explore this box plot interactively →