Protein localization to ciliary membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to ciliary membrane pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL13B, ARL3, and WDR19, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to ciliary membrane activity versus ARL13B in URINARY_TRACT (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARL13B →	+1.376	+0.123	.001	<.001	3	18
SOFT_TISSUE	ARL3 →	+1.099	+0.098	<.001	<.001	3	17
URINARY_TRACT	WDR19 →	+1.652	+0.139	<.001	<.001	3	17
BLOOD_Myeloma	KIF3A →	+1.032	+0.083	.002	.002	3	17
LIVER	IFT81 →	+1.429	+0.146	<.001	.003	3	16
URINARY_TRACT	HECTD2 →	+1.302	+0.130	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903441 vs ARL13B — URINARY_TRACT

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