Protein localization to ciliary membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to ciliary membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL3, GKAP1, and CUEDC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to ciliary membrane activity versus ARL3 in LARGE_INTESTINE (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARL3 →	+0.881	+0.296	<.001	.009	3	7
BLOOD_Leukemia	GKAP1 →	+1.028	+0.355	<.001	.001	3	6
STOMACH	CUEDC2 →	+1.144	+0.497	.004	.006	3	6
BLOOD_Leukemia	TLCD3B →	+1.019	+0.313	.004	.006	3	5
SKIN	CENPU →	+0.576	+0.347	.003	<.001	3	5
BLOOD_Leukemia	ACY1 →	-1.399	-0.447	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903441 vs ARL3 — LARGE_INTESTINE

Explore this scatter interactively →