Response to bile acid

Across TCGA patient cohorts, RNA activity of the Response to bile acid pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MEN1, SEC63_T537, and VAV2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to bile acid activity versus MEN1 in HNSC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEN1 →	-0.230	-0.118	<.001	<.001	3	6
COAD	SEC63_T537 →	+0.555	+0.078	<.001	<.001	3	5
COAD	VAV2 →	+0.405	+0.093	<.001	<.001	3	5
GBM	FAM76B_T215 →	-0.701	-0.058	<.001	<.001	3	5
GBM	MTA1_S449 →	-0.504	-0.072	<.001	<.001	3	5
BRCA	RPL18A →	+0.284	+0.050	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903412 vs MEN1 — HNSC

Explore this scatter interactively →