Positive regulation of mRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LUC7L3, IPO5, and MCM7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA metabolic process activity versus LUC7L3 in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LUC7L3 →	+0.497	+0.229	.007	.002	3	6
LARGE_INTESTINE	IPO5 →	+0.705	+0.158	.002	<.001	3	6
STOMACH	MCM7 →	+1.028	+0.241	.002	.008	2	6
BLOOD_Lymphoma	WDR74 →	+0.766	+0.145	<.001	<.001	3	5
BLOOD_Lymphoma	TMEM87B →	-0.663	-0.108	.001	.004	2	6
BLOOD_Leukemia	GVQW3 →	+0.766	+0.076	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903313 vs LUC7L3 — SOFT_TISSUE

Explore this scatter interactively →