Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNPY4, TRIM6, and FAM117B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tumor necrosis factor-mediated signaling pathway activity versus CNPY4 in OESOPHAGUS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CNPY4 →	-1.738	-0.868	<.001	.004	3	4
BONE	TRIM6 →	-2.738	-1.476	.007	.004	3	4
BONE	FAM117B →	+1.106	+1.219	.003	.002	3	4
BONE	ZYX →	-1.278	-1.315	.007	<.001	3	4
BONE	STAT3 →	-1.214	-1.598	.005	.001	3	4
CNS	FKBP15 →	-0.445	-0.690	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903265 vs CNPY4 — OESOPHAGUS

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