Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Positive regulation of tumor necrosis factor-mediated signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and CHOL, show the opposite pattern, with higher activity associated with better survival.

MESO, UVM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.270	0.494	.001	81	view →
UVM	OS	Median	All	0.430	0.715	.004	69	view →
BRCA	OS	Tertile	III,IV	0.759	0.432	<.001	50	view →
LIHC	DFS	Median	All	0.218	0.347	<.001	49	view →
LGG	OS	Median	All	0.358	0.501	<.001	38	view →
DLBC	DFS	Median	III,IV	0.137	0.761	.014	33	view →
GBM	OS	Median	All	0.334	0.486	.002	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
CHOL	DFS	Median	All	0.762	0.120	.002	21	view →
UCEC	OS	Median	All	0.613	0.728	.007	18	view →
COAD	DFS	Median	III,IV	0.251	0.510	.015	12	view →
STAD	OS	Tertile	IV	0.510	0.133	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:1903265–MESO (OS)

Open the MESO breakdown →