Protein localization to condensed chromosome

Across TCGA patient cohorts, RNA activity of the Protein localization to condensed chromosome pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RPL12_S38, and SETDB1_S1066, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to condensed chromosome activity versus RFC2 in GBM (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC2 →	+0.493	+0.156	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.378	+0.139	<.001	<.001	3	10
LUAD	SETDB1_S1066 →	+1.101	+0.151	<.001	<.001	3	10
LUAD	SMC2 →	+0.743	+0.148	<.001	<.001	3	10
LUAD	SMC4 →	+0.732	+0.153	<.001	<.001	3	10
LUAD	TK1 →	+0.763	+0.147	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903083 vs RFC2 — GBM

Explore this scatter interactively →