Positive regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, MYO6, and PPL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glycoprotein metabolic process activity versus UCK2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UCK2 →	-0.839	-0.366	<.001	.002	3	7
BONE	MYO6 →	+1.444	+0.459	.005	.002	2	7
PANCREAS	PPL →	+1.888	+0.234	.006	.003	3	6
URINARY_TRACT	BICDL2 →	+3.650	+0.281	<.001	<.001	2	7
BREAST	ESRP2 →	+1.710	+0.219	.003	.002	3	5
BREAST	C3orf52 →	+0.780	+0.225	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903020 vs UCK2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →