Regulation of bone development

Across TCGA cell cohorts, RNA activity of the Regulation of bone development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1A, LHFPL6, and NT5E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO1A grouped by Regulation of bone development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYO1A →	+0.298	+1.003	.006	.001	3	4
BREAST	LHFPL6 →	-1.625	-0.897	.002	.003	3	4
OVARY	NT5E →	-2.360	-0.795	<.001	.004	3	4
BLOOD_Leukemia	ILK →	+0.957	+0.944	<.001	.002	3	4
PANCREAS	EHD3 →	+1.719	+1.294	.008	.003	3	4
PANCREAS	CEP170 →	+0.843	+1.103	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO1A by Regulation of bone development activity — BREAST

Explore this box plot interactively →