Regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGMAR1, ANKRD27, and CDR2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid precursor protein catabolic process activity versus SIGMAR1 in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SIGMAR1 →	-0.979	-0.324	<.001	.003	3	4
STOMACH	ANKRD27 →	-1.328	-0.351	<.001	.005	3	3
LUNG_NSCLC_LUSC	CDR2L →	-1.785	-0.382	.006	.002	3	3
STOMACH	CLUH →	-1.108	-0.313	.007	.007	2	4
CNS	TAF1C →	-0.640	-0.253	.008	<.001	3	3
BONE	WDR27 →	-1.905	-0.355	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902991 vs SIGMAR1 — STOMACH

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