Negative regulation of response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARVG, HOMER1, and XKR8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to oxidative stress activity versus PARVG in LSCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PARVG →	+0.567	+0.827	<.001	<.001	3	4
HNSC	HOMER1 →	-0.517	-0.537	.008	.005	3	4
HNSC	XKR8 →	+0.346	+0.573	<.001	<.001	3	4
GBM	PRKCB →	+1.160	+0.718	<.001	<.001	3	4
GBM	CX3CR1 →	+0.925	+0.763	.004	<.001	3	4
GBM	TMEM119 →	+0.959	+0.662	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902883 vs PARVG — LSCC

Explore this scatter interactively →