Regulation of response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Regulation of response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXPE3, ZNF385B, and PID1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to oxidative stress activity versus NXPE3 in GBM (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NXPE3 →	+0.476	+0.136	<.001	.004	3	4
GBM	ZNF385B →	+0.676	+0.162	<.001	<.001	3	3
PDAC	PID1 →	+0.490	+0.182	.001	.003	3	3
PDAC	OR5B12 →	+0.032	+0.168	.004	<.001	3	3
BRCA	IL11RA →	+0.453	+0.384	.006	.005	2	4
GBM	CNN3P1 →	+0.261	+0.186	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902882 vs NXPE3 — GBM

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