Microtubule cytoskeleton organization involved in mitosis

Across TCGA patient cohorts, RNA activity of the Microtubule cytoskeleton organization involved in mitosis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ECT2_T359, SMC4, and TOP2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule cytoskeleton organization involved in mitosis activity versus ECT2_T359 in LUAD (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ECT2_T359 →	+1.802	+0.107	<.001	<.001	3	10
LUAD	SMC4 →	+0.714	+0.106	<.001	<.001	3	10
LUAD	TOP2A →	+1.220	+0.111	<.001	<.001	3	10
LUAD	HAT1 →	+0.451	+0.081	<.001	<.001	3	10
LUAD	NCAPD2 →	+0.816	+0.102	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.413	+0.098	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902850 vs ECT2_T359 — LUAD

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