Positive regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G1/S phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, PTPN2_S304, and MSH6_S830, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G1/S phase transition activity versus SMC4 in BRCA (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	+0.602	+0.047	<.001	<.001	3	9
LSCC	PTPN2_S304 →	+0.588	+0.032	<.001	.004	3	9
LUAD	MSH6_S830 →	+0.874	+0.051	<.001	<.001	3	9
LUAD	RRM2 →	+0.624	+0.053	<.001	<.001	3	8
LUAD	MCM4_S120 →	+1.167	+0.057	<.001	<.001	3	8
PDAC	TOP2A_S1377 →	+1.285	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902808 vs SMC4 — BRCA

Explore this scatter interactively →