Negative regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FST, EXT1, and PTPN14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FST grouped by Negative regulation of stem cell population maintenance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FST →	+3.917	+0.264	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	EXT1 →	+1.328	+0.183	.008	.006	3	5
BREAST	PTPN14 →	+1.042	+0.198	<.001	<.001	3	5
SOFT_TISSUE	GPR176 →	+2.415	+0.440	.009	.006	3	4
KIDNEY	PPFIBP1 →	+1.151	+0.289	.007	.001	3	4
BLOOD_Lymphoma	URGCP →	+1.000	+0.350	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FST by Negative regulation of stem cell population maintenance activity — PANCREAS

Explore this box plot interactively →