Regulation of mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K4, UBASH3B, and THAP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic cytokinesis activity versus MAP4K4 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAP4K4 →	+0.991	+0.158	<.001	<.001	3	6
OVARY	UBASH3B →	+1.619	+0.158	.004	.008	2	6
BONE	THAP5 →	+1.100	+0.148	.001	.003	3	5
STOMACH	NDUFA10 →	-0.779	-0.354	.001	.003	3	5
BLOOD_Leukemia	ACY1 →	-1.352	-0.125	<.001	.009	3	4
BLOOD_Leukemia	SMIM17 →	+0.403	+0.133	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902412 vs MAP4K4 — BLOOD_Leukemia

Explore this scatter interactively →