Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NEURL4_S907, FLNB_S1988, and AATF_S316, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus NEURL4_S907 in LSCC (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NEURL4_S907 →	-0.761	-1.400	<.001	<.001	3	3
GBM	FLNB_S1988 →	-1.288	-0.289	<.001	<.001	3	3
UCEC	AATF_S316 →	-1.026	-1.178	<.001	<.001	3	2
HNSC	TFEB_S455 →	-1.477	-1.291	<.001	<.001	3	2
BRCA	TNN →	-0.728	-0.572	<.001	<.001	3	2
HNSC	TNS1_S547 →	+0.840	+2.049	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902237 vs NEURL4_S907 — LSCC

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