Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC13D, FUT1, and CD82, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNC13D grouped by Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UNC13D →	+2.403	+0.786	<.001	.004	2	5
BLOOD_Leukemia	FUT1 →	+2.231	+1.145	.003	.003	3	4
BLOOD_Leukemia	CD82 →	+2.683	+1.321	.002	.001	3	4
LUNG_NSCLC_LUAD	AP4M1 →	-0.564	-0.546	.002	.002	3	4
URINARY_TRACT	ZNF460 →	+0.899	+0.583	.003	.002	3	4
BREAST	RGL3 →	+2.559	+0.964	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC13D by Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors activity — OVARY

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