Regulation of NADP metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of NADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, PLPPR5, and RNF214, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NADP metabolic process activity versus SCARB1 in SKIN (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCARB1 →	+1.434	+0.391	<.001	.005	3	4
URINARY_TRACT	PLPPR5 →	-0.157	-1.269	.008	.001	3	3
URINARY_TRACT	RNF214 →	+0.961	+1.317	<.001	<.001	3	3
CNS	CCDC151 →	-0.735	-0.789	<.001	.002	3	3
LUNG_NSCLC_LUAD	PPFIBP1 →	-0.688	-0.559	.005	<.001	3	3
PANCREAS	PRSS3 →	-3.229	-0.951	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902031 vs SCARB1 — SKIN

Explore this scatter interactively →