Regulation of cell communication by electrical coupling involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Regulation of cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMK2D, RFC4, and ALDH3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling involved in cardiac conduction activity versus CAMK2D in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAMK2D →	+0.487	+0.074	<.001	<.001	3	6
LSCC	RFC4 →	-0.328	-0.044	<.001	<.001	3	6
GBM	ALDH3B1 →	+0.617	+0.092	<.001	<.001	3	5
LUAD	RBBP5_S497 →	-0.686	-0.064	.002	<.001	3	5
COAD	HAUS1 →	-0.298	-0.055	<.001	<.001	3	5
LUAD	MCM3 →	-0.424	-0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901844 vs CAMK2D — BRCA

Explore this scatter interactively →