Negative regulation of proteasomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, KLHL3, and ZNF98, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteasomal protein catabolic process activity versus MAP1A in UCEC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1A →	+0.933	+0.325	<.001	<.001	2	6
GBM	KLHL3 →	+0.704	+0.272	<.001	<.001	3	4
GBM	ZNF98 →	+0.669	+0.232	<.001	<.001	3	4
LSCC	MAP1B →	+1.229	+0.196	<.001	.001	3	4
HNSC	BEND6 →	+0.613	+0.114	.007	.009	3	4
UCEC	ZNF208 →	+0.620	+0.241	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901799 vs MAP1A — UCEC

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